Leuprolide acetate
GnRH agonist used to down-regulate, or as an alternative trigger
Sold as Lupron, Lupron Depot
- Not yet available
A gonadotropin-releasing-hormone agonist. In a long agonist protocol it suppresses the body's own hormone signalling before stimulation begins; in antagonist cycles a single dose is sometimes used as the ovulation trigger instead of hCG, an approach associated with a lower risk of ovarian hyperstimulation.
When it is given
Either as daily injections starting in the cycle before stimulation (long agonist protocol), or as a one-off trigger injection at the end of stimulation.
What it actually costs
The national average price a US pharmacy pays to acquire this drug, published by CMS for every priced package. A wholesale floor, not a retail quote.
No published generic acquisition price
CMS publishes an average acquisition cost only for drugs with generic pharmacy supply. Biologic gonadotropins usually have none, so no figure is shown here rather than an estimated one.
Across a whole stimulation cycle, medication typically totals $3,000–$7,000, which is the number that matters for a budget. See the full cycle breakdown or how families pay for it.
What the prescribing information says
The current FDA structured product label, as published through openFDA and DailyMed. Excerpted verbatim, not summarised.
No FDA label indexed yet
The label feed has not returned a structured label for this medication. Nothing is shown rather than a paraphrase.
About Leuprolide acetate
What is Leuprolide acetate used for in fertility treatment?
A gonadotropin-releasing-hormone agonist. In a long agonist protocol it suppresses the body's own hormone signalling before stimulation begins; in antagonist cycles a single dose is sometimes used as the ovulation trigger instead of hCG, an approach associated with a lower risk of ovarian hyperstimulation. Either as daily injections starting in the cycle before stimulation (long agonist protocol), or as a one-off trigger injection at the end of stimulation.
How is Leuprolide acetate given?
Injectable. Either as daily injections starting in the cycle before stimulation (long agonist protocol), or as a one-off trigger injection at the end of stimulation.
Why is there no listed price for Leuprolide acetate?
CMS publishes a national average acquisition cost only for drugs with generic pharmacy supply, and Leuprolide acetate has no published generic acquisition price. Rather than estimate one, this page leaves it absent. Across a whole IVF cycle, stimulation medication typically totals $3,000 to $7,000.
Is Leuprolide acetate FDA-approved for fertility use?
Leuprolide's marketed FDA labels cover endometriosis, uterine fibroids, prostate cancer, and central precocious puberty, so the label below describes those uses. Its role in an IVF protocol is off-label and well established in practice.
Other medications in a cycle
- Ganirelix acetateGnRH antagonist that blocks a premature LH surgePreventing early ovulation
- Cetrorelix acetateGnRH antagonist that blocks a premature LH surgePreventing early ovulation
- LetrozoleOvulation induction (commonly first-line for PCOS)Ovulation induction
- Clomiphene citrateOvulation inductionOvulation induction