Preventing early ovulationInjectable

Ganirelix (Fyremadel)

GnRH antagonist that blocks a premature LH surge

Sold as generic ganirelix acetate

Updated weekly · checked 16 h ago
$45.25lowest posted cash price per 250 mcg syringe
$31.17per 0.5 mL package, what pharmacies pay
639FAERS reports (all-time)

Ganirelix costs $45.25 to $49.90 per 250 mcg syringe at the 2 sources that post a cash price, lowest at Mark Cuban Cost Plus Drugs (prices read Oct 4, 2026); a drug-price guide lists $37.38 per 250 mcg syringe at an ordinary retail pharmacy; pharmacies themselves pay a national average of $31.17 per 0.5 mL package to acquire it (CMS NADAC).

A gonadotropin-releasing-hormone antagonist that suppresses the body's own LH surge within hours, so follicles are not released before the egg retrieval. The antagonist protocol built around it is the most common modern IVF stimulation.

Cost

What Ganirelix costs, by pharmacy

Every cash price we found posted by a pharmacy, TrumpRx.gov or the manufacturer, read on the seller's own page on Oct 4, 2026, compared per one unit and cheapest first. A retail drug-price guide's figure is shown for context.

Where, and the product as listedPer 250 mcg syringe
  • Drugs.com price guideRetail price guide
    Ganirelix 250 mcg/0.5 mL, 1 syringe: from $37.38 for 0.5 milliliters
    Drugs.com lists $37.38 to $154.71 for one syringe, by product.
    $37.38
    read Oct 4, 2026
  • Mark Cuban Cost Plus DrugsCash pharmacy
    Ganirelix acetate 250 mcg/0.5 mL prefilled syringe (generic): Your Drug Price With Us: $45.25
    Shipping $5.25.
    $45.25
    read Oct 4, 2026
  • Mandell's Clinical PharmacyFertility pharmacy
    Ganirelix 250 mcg prefilled syringe: $ 49.90
    Estimate; service fee added at checkout.
    $49.90
    read Oct 4, 2026

Cash prices only: with insurance that covers fertility drugs you pay your plan's share instead, and most manufacturer programs cannot be combined with insurance. Prices change; each row links to the page it was read on. Compare every IVF medication, or see what a whole cycle's drugs cost after TrumpRx.

Savings

Programs that lower the cost of Ganirelix

Each program's own terms, read on its page. Eligibility is the program's to decide.

  • ReUnite RxOrganon, run by ReUnite Rx

    Reduced everyday cash prices on Follistim AQ, Organon's ganirelix and Pregnyl at ReUnite network pharmacies. The prices are not published: the pharmacy quotes them.

    Who qualifies: Patients not using insurance for their fertility medications.

    How to enroll: No application or card: a ReUnite network pharmacy enrolls you when it fills the prescription. 844-385-5403.

    Read Oct 4, 2026

  • ReUnite OncofertilityOrganon, run by ReUnite Rx

    Up to 100% off the patient's cost, based on clinical and financial need, up to 2,700 IU of Follistim AQ, 5 ganirelix syringes and one 10,000 IU vial of Pregnyl.

    Who qualifies: Women who need cancer treatment that affects fertility, with no prior chemotherapy, paying for fertility drugs themselves, with proof of income and a form from the oncologist.

    How to enroll: Apply online through the ReUnite Rx portal with the oncologist form.

    Read Oct 4, 2026

What pharmacies pay

The national acquisition cost (CMS NADAC)

The national average price a US retail pharmacy pays to acquire each product, published weekly by CMS. A wholesale floor, not the price you are charged.

Package (NDC description)Per unit
  • Ganirelix Acet 250 MCG/0.5 ML
    NDC 83301008201 · effective Feb 25, 2026
    $62.35
    / mL
    $31.17 per 0.5 mL package
  • Fyremadel 250 MCG/0.5 ML Syr
    NDC 55566101001 · effective Dec 17, 2025
    $62.35
    / mL
    $31.17 per 0.5 mL syringe

Source: CMS National Average Drug Acquisition Cost (NADAC) · as of Feb 25, 2026

Across a whole stimulation cycle, all the medications together typically total $3,000–$7,000, which is the number that matters for a budget. See the full cycle breakdown or how families pay for it.

In a cycle

When it is given

Started partway through stimulation, once follicles reach a certain size, and continued as a daily injection until the trigger shot.

FDA label

What the prescribing information says

The current FDA structured product label, as published through openFDA and DailyMed. Excerpted verbatim, not summarised.

What the FDA label approves it for

INDICATIONS AND USAGE Ganirelix Acetate Injection is indicated for the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation.

Dosage and administration

DOSAGE AND ADMINISTRATION After initiating FSH therapy on Day 2 or 3 of the cycle, ganirelix acetate injection 250 mcg may be administered subcutaneously once daily during the mid to late portion of the follicular phase. By taking advantage of endogenous pituitary FSH secretion, the requirement for exogenously administered FSH may be reduced. Treatment with ganirelix acetate should be continued daily until the day of hCG administration. When a sufficient number of follicles of adequate size are present, as assessed by ultrasound, final maturation of follicles is induced by administering hCG. The administration of hCG should be withheld in cases where the ovaries are abnormally enlarged on the last day of FSH therapy to reduce the chance of developing OHSS (Ovarian Hyperstimulation Syndrome). Directions for Using Ganirelix Acetate Injection Ganirelix acetate injection is supplied in a single dose, sterile, prefilled syringe and is intended for SUBCUTANEOUS administration only. Air bubble(s) may be seen in the pre-filled syringe. This is expected, and removal of the air bubble(s) is not needed. Wash hands thoroughly with soap and water. The most convenient sites for SUBCUTANEOUS inje

Warnings and cautions

WARNINGS Ganirelix acetate injection should be prescribed by physicians who are experienced in infertility treatment. Before starting treatment with ganirelix acetate, pregnancy must be excluded. Safe use of ganirelix acetate during pregnancy has not been established (see CONTRAINDICATIONS and PRECAUTIONS ).

Contraindications

CONTRAINDICATIONS Ganirelix acetate is contraindicated under the following conditions: Known hypersensitivity to ganirelix acetate or to any of its components including dry natural rubber/latex (see HOW SUPPLIED ). Known hypersensitivity to GnRH or any other GnRH analog. Known or suspected pregnancy (see PRECAUTIONS ).

Label for Ganirelix Acetate, source: openFDA structured product labels · as of Oct 18, 2026

Reported adverse events

What has been reported to the FDA

FAERS is a voluntary reporting system. A high count reflects how widely a drug is used and how often people report, not how dangerous it is, and a report is not proof the drug caused the event.

639reports, all-time
361flagged serious
  • ovarian hyperstimulation syndrome 253
  • ascites 58
  • nausea 37
  • dyspnoea 34
  • abdominal pain 28
  • drug ineffective 27

Source: openFDA FAERS (drug adverse events) · as of Oct 20, 2026

Common questions

About Ganirelix

How much does Ganirelix cost?

Ganirelix costs $45.25 to $49.90 per 250 mcg syringe at the 2 sources that post a cash price, lowest at Mark Cuban Cost Plus Drugs (prices read Oct 4, 2026); a drug-price guide lists $37.38 per 250 mcg syringe at an ordinary retail pharmacy; pharmacies themselves pay a national average of $31.17 per 0.5 mL package to acquire it (CMS NADAC). Across a whole IVF cycle, all the medications together typically total $3,000 to $7,000.

Is there a savings program for Ganirelix?

Yes: ReUnite Rx (Organon, run by ReUnite Rx): Reduced everyday cash prices on Follistim AQ, Organon's ganirelix and Pregnyl at ReUnite network pharmacies. The prices are not published: the pharmacy quotes them. ReUnite Oncofertility (Organon, run by ReUnite Rx): Up to 100% off the patient's cost, based on clinical and financial need, up to 2,700 IU of Follistim AQ, 5 ganirelix syringes and one 10,000 IU vial of Pregnyl. Each program states its own eligibility; read it on the program's page before you fill the prescription.

What is Ganirelix used for in fertility treatment?

A gonadotropin-releasing-hormone antagonist that suppresses the body's own LH surge within hours, so follicles are not released before the egg retrieval. The antagonist protocol built around it is the most common modern IVF stimulation. Started partway through stimulation, once follicles reach a certain size, and continued as a daily injection until the trigger shot.

How is Ganirelix given?

Injectable. Started partway through stimulation, once follicles reach a certain size, and continued as a daily injection until the trigger shot.

Related

Other medications in a cycle

Posted cash prices are each seller's own published figure on the date shown; your price depends on the pharmacy, the quantity and your insurance. NADAC is the national average price a pharmacy pays to acquire a drug, not the price you are charged. Dosing here is quoted from the FDA label and is not a prescription: your protocol comes from your clinic. IVFcost.co is an informational data platform, not a medical provider, clinic, or laboratory. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Success rates depend heavily on individual circumstances and are not a promise of any outcome. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the clinic's own current figures.