Ovidrel (choriogonadotropin alfa)
The trigger shot that finishes egg maturation before retrieval
Ovidrel costs $84 per 250 mcg syringe at each of the 2 sources that post a cash price (prices read Oct 4, 2026); a drug-price guide lists $253.90 per 250 mcg syringe at an ordinary retail pharmacy; pharmacies themselves pay a national average of $242.72 per 0.5 mL syringe to acquire it (CMS NADAC).
Recombinant human chorionic gonadotropin made by EMD Serono, given as a single prefilled-syringe injection that mimics the natural LH surge and completes the final maturation of the eggs so they can be collected. Novarel and Pregnyl do the same job with hCG purified from urine.
What Ovidrel costs, by pharmacy
Every cash price we found posted by a pharmacy, TrumpRx.gov or the manufacturer, read on the seller's own page on Oct 4, 2026, compared per one unit and cheapest first. A retail drug-price guide's figure is shown for context.
- TrumpRx.govGovernment siteOvidrel 250 mcg prefilled syringe: TrumpRx Price $84.00Cash only. List price shown: $251.84.$84read Oct 4, 2026
- Mandell's Clinical PharmacyFertility pharmacyOvidrel 250 mcg prefilled syringe: $ 84Estimate; service fee added at checkout.$84read Oct 4, 2026
- Drugs.com price guideRetail price guideOvidrel 250 mcg prefilled syringe: from $253.90 for 0.5 milliliters$253.90read Oct 4, 2026
Cash prices only: with insurance that covers fertility drugs you pay your plan's share instead, and most manufacturer programs cannot be combined with insurance. Prices change; each row links to the page it was read on. Compare every IVF medication, or see what a whole cycle's drugs cost after TrumpRx.
Programs that lower the cost of Ovidrel
Each program's own terms, read on its page. Eligibility is the program's to decide.
- Fertility Instant SavingsEMD Serono
The same fixed cash prices as TrumpRx: Gonal-f $168 (300 IU pen), $252 (450 IU pen or multi-dose vial), $504 (900 IU pen); Cetrotide $22.50; Ovidrel $84, shipped at no cost.
Who qualifies: Anyone 18 or older in the US who pays for these EMD Serono medications out of pocket, with no insurance claim for them. No income test; insurance can still pay for the rest of treatment. Works for IVF, IUI, egg freezing, surrogacy and donation cycles.
How to enroll: A savings card issued instantly online, used at a participating pharmacy: Freedom Fertility, Village Fertility, Alto, Mandell's, Apri, Prima, CVS Specialty or SMP Pharmacy Solutions. Help line 1-866-538-7879.
Read Oct 4, 2026
- Compassionate CareEMD Serono
EMD Serono's deepest self-pay discount; its pages give no amount. The Council of Economic Advisers (May 2026) puts it at $25 per 75 IU of Gonal-f.
Who qualifies: Self-pay patients whose household income qualifies (checked against a tax return), 18 or older, not using insurance for these medications. EMD Serono does not publish the income limit; the White House Council of Economic Advisers describes the income-qualified price as for incomes below 550% of the federal poverty level.
How to enroll: Apply at fertilitysavings.com with a tax return; a decision takes 1 to 5 business days. Eligibility lasts 365 days, then reapply.
Read Oct 4, 2026
- Compassionate CorpsEMD Serono
Free medication, for up to 2 cycles a year.
Who qualifies: Medically retired military members or veterans (or their spouses) made infertile by a service-related injury, needing IVF, not insured for fertility medications and not eligible under the Fertility Veterans Act.
How to enroll: Call Fertility LifeLines at 1-866-538-7879 or apply through fertilitysavings.com; reapply each year.
Read Oct 4, 2026
- Livestrong FertilityLivestrong Foundation, with medication donated by EMD Serono
Free fertility stimulation medication from EMD Serono, plus at least 25% off services at partner clinics.
Who qualifies: A cancer diagnosis whose treatment may affect fertility, lawfully present in the US, at a Livestrong partner clinic. For the person freezing eggs or embryos: household income up to $130,000 single or $170,000 married, with no or limited insurance for it.
How to enroll: Online application at livestrong.org after an eligibility checklist, with a letter from the oncology team; (855) 844-7777.
Read Oct 4, 2026
The national acquisition cost (CMS NADAC)
The national average price a US retail pharmacy pays to acquire each product, published weekly by CMS. A wholesale floor, not the price you are charged.
- Ovidrel 250 MCG/0.5 ML SyrgNDC 44087115001 · effective Sep 23, 2026
Source: CMS National Average Drug Acquisition Cost (NADAC) · as of Sep 23, 2026
Across a whole stimulation cycle, all the medications together typically total $3,000–$7,000, which is the number that matters for a budget. See the full cycle breakdown or how families pay for it.
When it is given
A single injection at a precisely scheduled time once follicles reach maturity, timed to the retrieval that follows roughly a day and a half later. The exact timing is the reason clinics are strict about the trigger hour.
What the prescribing information says
The current FDA structured product label, as published through openFDA and DailyMed. Excerpted verbatim, not summarised.
What the FDA label approves it for
INDICATIONS AND USAGE Ovidrel ® PreFilled Syringe (choriogonadotropin alfa injection) is indicated for the induction of final follicular maturation and early luteinization in infertile women who have undergone pituitary desensitization and who have been appropriately pretreated with follicle stimulating hormones as part of an Assisted Reproductive Technology (ART) program such as in vitro fertilization and embryo transfer. Ovidrel ® PreFilled Syringe is also indicated for the induction of ovulation (OI) and pregnancy in anovulatory infertile patients in whom the cause of infertility is functional and not due to primary ovarian failure. Selection of Patients Before treatment with gonadotropins is instituted, a thorough gynecologic and endocrinologic evaluation must be performed. This should include an assessment of pelvic anatomy. Patients with tubal obstruction should receive Ovidrel ® PreFilled Syringe only if enrolled in an in vitro fertilization program. Primary ovarian failure should be excluded by the determination of gonadotropin levels. Appropriate evaluation should be performed to exclude pregnancy. Patients in later reproductive life have a greater predisposition to endome
Dosage and administration
DOSAGE AND ADMINISTRATION For Subcutaneous Use Only Infertile Women Undergoing Assisted Reproductive Technologies (ART) Ovidrel ® PreFilled Syringe 250 µg should be administered one day following the last dose of the follicle stimulating agent. Ovidrel ® PreFilled Syringe should not be administered until adequate follicular development is indicated by serum estradiol and vaginal ultrasonography. Administration should be withheld in situations where there is an excessive ovarian response, as evidenced by clinically significant ovarian enlargement or excessive estradiol production. Infertile Women Undergoing Ovulation Induction (OI) Ovidrel ® PreFilled Syringe should not be administered until adequate follicular development is indicated by serum estradiol and vaginal ultrasonography. Ovidrel ® PreFilled Syringe 250 µg should be administered one day following the last dose of the follicle stimulating agent. Ovidrel ® PreFilled Syringe administration should be withheld in situations where there is an excessive ovarian response, as evidenced by multiple follicular development, clinically significant ovarian enlargement or excessive estradiol production. Directions for Administration of
Warnings and cautions
WARNINGS Gonadotropins, including Ovidrel ® PreFilled Syringe (choriogonado-tropin alfa injection), should only be used by physicians who are thoroughly familiar with infertility problems and their management. Like other hCG products, Ovidrel ® PreFilled Syringe is a potent gonadotropic substance capable of causing Ovarian Hyperstimulation Syndrome (OHSS) in women with or without pulmonary or vascular complications. The risks of gonadoptropin treatment should be considered for women with risk factors of thromboembolic events such as prior medical or family history. Gonadotropin therapy requires a certain time commitment by physicians and supportive health professionals, and requires the availability of appropriate monitoring facilities (see " Precautions/ Laboratory Tests "). Safe and effective induction of ovulation and use of Ovidrel ® PreFilled Syringe in women requires monitoring of ovarian response with serum estradiol and transvaginal ultrasound on a regular basis. Overstimulation of the Ovary Following hCG Therapy Ovarian Enlargement Mild to moderate uncomplicated ovarian enlargement which may be accompanied by abdominal distention and/or abdominal pain may occur in patients
Contraindications
CONTRAINDICATIONS Ovidrel ® PreFilled Syringe (choriogonadotropin alfa injection) is contraindicated in women who exhibit: Prior hypersensitivity to hCG preparations or one of their excipients. Primary ovarian failure. Uncontrolled thyroid or adrenal dysfunction. An uncontrolled organic intracranial lesion such as a pituitary tumor. Abnormal uterine bleeding of undetermined origin (see " Selection of Patients " ). Ovarian cyst or enlargement of undetermined origin (see " Selection of Patients " ). Sex hormone dependent tumors of the reproductive tract and accessory organs. Pregnancy.
Label for Ovidrel, source: openFDA structured product labels · as of Oct 4, 2026
What has been reported to the FDA
FAERS is a voluntary reporting system. A high count reflects how widely a drug is used and how often people report, not how dangerous it is, and a report is not proof the drug caused the event.
- ovarian hyperstimulation syndrome 624
- no adverse event 208
- product dose omission issue 110
- abdominal distension 100
- ascites 90
- nausea 87
Source: openFDA FAERS (drug adverse events) · as of Sep 29, 2026
About Ovidrel
How much does Ovidrel cost?
Ovidrel costs $84 per 250 mcg syringe at each of the 2 sources that post a cash price (prices read Oct 4, 2026); a drug-price guide lists $253.90 per 250 mcg syringe at an ordinary retail pharmacy; pharmacies themselves pay a national average of $242.72 per 0.5 mL syringe to acquire it (CMS NADAC). Across a whole IVF cycle, all the medications together typically total $3,000 to $7,000.
Is there a savings program for Ovidrel?
Yes: Fertility Instant Savings (EMD Serono): The same fixed cash prices as TrumpRx: Gonal-f $168 (300 IU pen), $252 (450 IU pen or multi-dose vial), $504 (900 IU pen); Cetrotide $22.50; Ovidrel $84, shipped at no cost. Compassionate Care (EMD Serono): EMD Serono's deepest self-pay discount; its pages give no amount. The Council of Economic Advisers (May 2026) puts it at $25 per 75 IU of Gonal-f. Compassionate Corps (EMD Serono): Free medication, for up to 2 cycles a year. Livestrong Fertility (Livestrong Foundation, with medication donated by EMD Serono): Free fertility stimulation medication from EMD Serono, plus at least 25% off services at partner clinics. Each program states its own eligibility; read it on the program's page before you fill the prescription.
What is Ovidrel used for in fertility treatment?
Recombinant human chorionic gonadotropin made by EMD Serono, given as a single prefilled-syringe injection that mimics the natural LH surge and completes the final maturation of the eggs so they can be collected. Novarel and Pregnyl do the same job with hCG purified from urine. A single injection at a precisely scheduled time once follicles reach maturity, timed to the retrieval that follows roughly a day and a half later. The exact timing is the reason clinics are strict about the trigger hour.
How is Ovidrel given?
Injectable. A single injection at a precisely scheduled time once follicles reach maturity, timed to the retrieval that follows roughly a day and a half later. The exact timing is the reason clinics are strict about the trigger hour.
Other medications in a cycle
- Novarel, Pregnyl and generic hCGThe trigger shot that finishes egg maturation before retrievalTrigger
- Letrozole (Femara)Ovulation induction (commonly first-line for PCOS)Ovulation induction
- Clomid (clomiphene citrate)Ovulation inductionOvulation induction
- Gonal-f (follitropin alfa)Controlled ovarian stimulation for IVFOvarian stimulation