Novarel, Pregnyl and generic hCG
The trigger shot that finishes egg maturation before retrieval
hCG costs $149.90 to $218 per 10,000 units at Mandell's Clinical Pharmacy, the one source we found that posts a cash price (prices read Oct 4, 2026); a drug-price guide lists $182.10 per 10,000 units at an ordinary retail pharmacy; pharmacies themselves pay a national average of $171.53 per vial to acquire it (CMS NADAC).
Human chorionic gonadotropin purified from urine, sold as Novarel (Ferring), Pregnyl (Organon) and generic chorionic gonadotropin in vials of powder that are mixed before the injection. It mimics the natural LH surge to finish egg maturation, the job Ovidrel does with a recombinant hormone.
What hCG costs, by pharmacy
Every cash price we found posted by a pharmacy, TrumpRx.gov or the manufacturer, read on the seller's own page on Oct 4, 2026, compared per one unit and cheapest first. A retail drug-price guide's figure is shown for context.
- Mandell's Clinical PharmacyFertility pharmacyChorionic gonadotropin (hCG) 10,000 unit vial: $ 149.90Estimate; service fee added at checkout.$149.90read Oct 4, 2026
- Drugs.com price guideRetail price guidePregnyl 10,000 units, 1 vial: from $182.10 for 1 powder for injection$182.10read Oct 4, 2026
- Mandell's Clinical PharmacyFertility pharmacyNovarel 5,000 unit vial: $ 109Estimate; service fee added at checkout.$218read Oct 4, 2026
- Drugs.com price guideRetail price guideChorionic gonadotropin (generic) 10,000 units, 1 vial: from $355.60 for 1 powder for injection$355.60read Oct 4, 2026
- Drugs.com price guideRetail price guideNovarel 5,000 units, 1 vial: from $181.02 for 1 powder for injection$362.04read Oct 4, 2026
Cash prices only: with insurance that covers fertility drugs you pay your plan's share instead, and most manufacturer programs cannot be combined with insurance. Prices change; each row links to the page it was read on. Compare every IVF medication, or see what a whole cycle's drugs cost after TrumpRx.
Programs that lower the cost of hCG
Each program's own terms, read on its page. Eligibility is the program's to decide.
- Heart for HeroesFerring
Menopur, Endometrin and Novarel 5,000 units at no cost; other medications are not covered.
Who qualifies: Veterans medically separated from active duty (Department of Defense category 2 or 3) with a service-related injury causing infertility that needs assisted reproduction, or their spouses, with no insurance coverage for IVF medications; residents of the 50 states and DC.
How to enroll: The physician certifies eligibility and faxes the enrollment form to MDR specialty pharmacy, which ships the medication free.
Read Oct 4, 2026
- ReUnite RxOrganon, run by ReUnite Rx
Reduced everyday cash prices on Follistim AQ, Organon's ganirelix and Pregnyl at ReUnite network pharmacies. The prices are not published: the pharmacy quotes them.
Who qualifies: Patients not using insurance for their fertility medications.
How to enroll: No application or card: a ReUnite network pharmacy enrolls you when it fills the prescription. 844-385-5403.
Read Oct 4, 2026
- ReUnite OncofertilityOrganon, run by ReUnite Rx
Up to 100% off the patient's cost, based on clinical and financial need, up to 2,700 IU of Follistim AQ, 5 ganirelix syringes and one 10,000 IU vial of Pregnyl.
Who qualifies: Women who need cancer treatment that affects fertility, with no prior chemotherapy, paying for fertility drugs themselves, with proof of income and a form from the oncologist.
How to enroll: Apply online through the ReUnite Rx portal with the oncologist form.
Read Oct 4, 2026
The national acquisition cost (CMS NADAC)
The national average price a US retail pharmacy pays to acquire each product, published weekly by CMS. A wholesale floor, not the price you are charged.
Source: CMS National Average Drug Acquisition Cost (NADAC) · as of Sep 23, 2026
Across a whole stimulation cycle, all the medications together typically total $3,000–$7,000, which is the number that matters for a budget. See the full cycle breakdown or how families pay for it.
When it is given
A single injection at a precisely scheduled time once follicles reach maturity, timed to the retrieval that follows roughly a day and a half later. Some protocols also use smaller amounts at other points in a cycle; the clinic's instructions set every dose.
What the prescribing information says
The current FDA structured product label, as published through openFDA and DailyMed. Excerpted verbatim, not summarised.
What the FDA label approves it for
INDICATIONS AND USAGE HCG HAS NOT BEEN DEMONSTRATED TO BE EFFECTIVE ADJUNCTIVE THERAPY IN THE TREATMENT OF OBESITY. THERE IS NO SUBSTANTIAL EVIDENCE THAT IT INCREASES WEIGHT LOSS BEYOND THAT RESULTING FROM CALORIC RESTRICTION, THAT IT CAUSES A MORE ATTRACTIVE OR "NORMAL" DISTRIBUTION OF FAT, OR THAT IT DECREASES THE HUNGER AND DISCOMFORT ASSOCIATED WITH CALORIE-RESTRICTED DIETS. Prepubertal cryptorchidism not due to anatomic obstruction. In general, HCG is thought to induce testicular descent in situations when descent would have occurred at puberty. HCG thus may help to predict whether or not orchiopexy will be needed in the future. Although, in some cases, descent following HCG administration is permanent, in most cases the response is temporary. Therapy is usually instituted between the ages of 4 and 9. Selected cases of hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males. Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins.
Dosage and administration
DOSAGE AND ADMINISTRATION (Intramuscular Use Only): The dosage regimen employed in any particular case will depend upon the indication for use, the age and weight of the patient, and the physician's preference. The following regimens have been advocated by various authorities. Prepubertal cryptorchidism not due to anatomical obstruction: 4,000 USP Units three times weekly for three weeks. 5,000 USP Units every second day for four injections. 15 injections of 500 to 1,000 USP Units over a period of six weeks. 500 USP Units three times weekly for four to six weeks. If this course of treatment is not successful, another is begun one month later, giving 1,000 USP Units per injection. Selected cases of hypogonadotropic hypogonadism in males: 500 to 1,000 USP Units three times a week for three weeks, followed by the same dose twice a week for three weeks. 4,000 USP Units three times weekly for six to nine months, following which the dosage may be reduced to 2,000 USP Units three times weekly for an additional three months. Table 1. Final Concentration after Reconstitution Reconstitution volume of bacteriostatic water for injection 10,000 IU Vial Concentration 5,000 IU Vial Concentration
Warnings and cautions
WARNINGS HCG should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warnings, precautions, and adverse reactions described in the package insert for menotropins. The principal serious adverse reactions during this use are: (1) Ovarian hyperstimulation, a syndrome of sudden ovarian enlargement, ascites with or without pain, and/or pleural effusion; (2) Enlargement of preexisting ovarian cysts or rupture of ovarian cysts with resultant hemoperitoneum; (3) Multiple births, and (4) Arterial thromboembolism. The recommended diluent for reconstitution is Bacteriostatic Water for Injection preserved with benzyl alcohol 0.9%. Benzyl alcohol has been reported to be associated with a fatal "Gasping Syndrome" in premature infants. Anaphylaxis has been reported with urinary-derived HCG products.
Contraindications
CONTRAINDICATIONS Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG. HCG may cause fetal harm when administered to a pregnant woman. Combined HCG/PMS (pregnant mare's serum) therapy has been noted to induce high incidences of external congenital anomalies in the offspring of mice, in a dose-dependent manner. The potential extrapolation to humans has not been determined.
Label for Novarel, source: openFDA structured product labels · as of Oct 4, 2026
About hCG
How much does hCG cost?
hCG costs $149.90 to $218 per 10,000 units at Mandell's Clinical Pharmacy, the one source we found that posts a cash price (prices read Oct 4, 2026); a drug-price guide lists $182.10 per 10,000 units at an ordinary retail pharmacy; pharmacies themselves pay a national average of $171.53 per vial to acquire it (CMS NADAC). Across a whole IVF cycle, all the medications together typically total $3,000 to $7,000.
Is there a savings program for hCG?
Yes: Heart for Heroes (Ferring): Menopur, Endometrin and Novarel 5,000 units at no cost; other medications are not covered. ReUnite Rx (Organon, run by ReUnite Rx): Reduced everyday cash prices on Follistim AQ, Organon's ganirelix and Pregnyl at ReUnite network pharmacies. The prices are not published: the pharmacy quotes them. ReUnite Oncofertility (Organon, run by ReUnite Rx): Up to 100% off the patient's cost, based on clinical and financial need, up to 2,700 IU of Follistim AQ, 5 ganirelix syringes and one 10,000 IU vial of Pregnyl. Each program states its own eligibility; read it on the program's page before you fill the prescription.
What is hCG used for in fertility treatment?
Human chorionic gonadotropin purified from urine, sold as Novarel (Ferring), Pregnyl (Organon) and generic chorionic gonadotropin in vials of powder that are mixed before the injection. It mimics the natural LH surge to finish egg maturation, the job Ovidrel does with a recombinant hormone. A single injection at a precisely scheduled time once follicles reach maturity, timed to the retrieval that follows roughly a day and a half later. Some protocols also use smaller amounts at other points in a cycle; the clinic's instructions set every dose.
How is hCG given?
Injectable. A single injection at a precisely scheduled time once follicles reach maturity, timed to the retrieval that follows roughly a day and a half later. Some protocols also use smaller amounts at other points in a cycle; the clinic's instructions set every dose.
Other medications in a cycle
- Ovidrel (choriogonadotropin alfa)The trigger shot that finishes egg maturation before retrievalTrigger
- Letrozole (Femara)Ovulation induction (commonly first-line for PCOS)Ovulation induction
- Clomid (clomiphene citrate)Ovulation inductionOvulation induction
- Gonal-f (follitropin alfa)Controlled ovarian stimulation for IVFOvarian stimulation