Fertility supplements, rated honestly
The ingredients sold for egg quality, sperm quality, and "fertility support," graded against the real evidence. None is a fertility drug.
8 ingredients marketed for fertility are graded here, each against the primary literature. None is a fertility drug or FDA-approved to treat infertility: a few carry a modest, genuine signal (folate before pregnancy is the clearest), but most do not match the marketing.
Every ingredient, with a verdict
Ranked by computed evidence score. The score reflects the volume and type of primary literature, not an endorsement.
Best-studied by the evidence: Folate (methylfolate) leads the field at ~88/100. A higher score means more and stronger research exists, not that it works better.
- Read the full breakdown of Folate (methylfolate)
Folate (methylfolate)
VitaminThe one non-negotiable: adequate folate before and during early pregnancy is genuinely evidence-based; the methylfolate-versus-folic-acid upsell is mostly marketing for most people.
- Read the full breakdown of Omega-3 (DHA/EPA fish oil)
Omega-3 (DHA/EPA fish oil)
Omega-3A reasonable, low-risk part of a preconception diet with clear pregnancy benefits, but only modest and uncertain evidence as a fertility enhancer.
- Read the full breakdown of Vitamin D
Vitamin D
VitaminWorth correcting a real deficiency (which is common), but not a fertility booster for people with normal levels; test first, do not megadose.
- Read the full breakdown of L-carnitine
L-carnitine
Amino acidThe male-fertility data are more developed than for most entries here but still limited; a plausible, low-risk adjunct rather than a proven treatment.
- Read the full breakdown of Coenzyme Q10 (CoQ10)
Coenzyme Q10 (CoQ10)
AntioxidantBiologically plausible and low-risk, but the fertility evidence is limited and preliminary; not a proven way to increase conception.
- Read the full breakdown of DHEA (dehydroepiandrosterone)
DHEA (dehydroepiandrosterone)
Hormone precursorA genuine clinical tool in specific IVF cases under a fertility doctor, but not a self-prescribed supplement; the evidence is weak and it carries real hormonal risks.
- Read the full breakdown of Myo-inositol
Myo-inositol
Insulin sensitizerAmong the better-evidenced options for PCOS-related ovulation problems, but the evidence quality is modest and it is not a general fertility booster.
- Read the full breakdown of N-acetylcysteine (NAC)
N-acetylcysteine (NAC)
AntioxidantBiologically plausible with some encouraging small PCOS data, but far from proven; treat it as adjunctive and evidence-limited.
The branded fertility supplements
The prenatals and preconception formulas people actually buy, what they contain, where they are sold, and the price. None is a fertility drug. Each links to its own source.
Contains: Methylated folate (as 5-MTHF), vegan omega-3 DHA (from algae), vitamin D3, choline, iron, vitamin B12, iodine, magnesium, boron, and vitamin K2, in a delayed-release capsule. No fertility drug.
Marketed as: Marketed as a traceable, science-backed prenatal for before and during pregnancy, with methylated folate and vegan DHA.
Price: ~$40 for a 30-day supply (subscription)
Sold via ritual.com, Amazon · A well-formulated prenatal covering the evidence-based basics (folate, DHA, iodine, vitamin D). It supports nutritional adequacy, not a guaranteed boost to conception.
Contains: A higher-dose prenatal multivitamin with methylated folate, methylated B12, vitamin D3, and chelated minerals. Choline and omega-3 are sold separately in their system. No fertility drug.
Marketed as: Marketed as a practitioner-grade prenatal designed to fill common nutrient gaps from preconception through postpartum.
Price: ~$50-$60/mo (subscription)
Sold via thisisneeded.com, select practitioners · A higher-dose, practitioner-oriented formula. Because choline and omega-3 are separate products, the true monthly cost is higher than the multi alone.
Contains: An egg-quality formula built around myo-inositol, plus folate (as 5-MTHF), vitamin D3, and antioxidants. No fertility drug.
Marketed as: Marketed to support egg quality and ovarian function for women trying to conceive, including those with PCOS.
Price: ~$40-$50 for a 1-month supply
Sold via theralogix.com, Amazon · Built on inositol, which has the most supportive evidence in PCOS, and independently (NSF) tested. Evidence for egg-quality claims in general, non-PCOS users remains limited.
Contains: A male-fertility antioxidant formula with L-carnitine, vitamin C, vitamin E, zinc, selenium, folate, and lycopene. No fertility drug.
Marketed as: Marketed to support sperm count, motility, and morphology through antioxidants and micronutrients.
Price: ~$45-$55 for a 1-month supply
Sold via theralogix.com, Amazon · Combines antioxidants with weak-to-moderate individual evidence (L-carnitine, zinc, selenium) and is NSF tested. The antioxidant benefit for male fertility is plausible but the trials are small and inconsistent.
Contains: A dietitian-formulated prenatal taken as 8 capsules a day (240 capsules, 30 servings): folate 1,360 mcg DFE as L-5-MTHF plus folinic acid, vitamin D3 4,000 IU (100 mcg), choline 300 mg, iodine 250 mcg, magnesium 300 mg, plus vitamin K2 and chelated minerals. Contains no iron and no omega-3 (taken separately). No fertility drug.
Marketed as: Marketed as a prenatal emphasizing choline and vitamin D, for preconception through breastfeeding.
Price: $49.95 for a 1-month supply
Sold via fullwellfertility.com, Amazon · Notable for its choline (300 mg, a nutrient many prenatals underdose) and vitamin D. Because it contains no iron or omega-3, those must be added separately. A prenatal, not a fertility treatment. Label and price read 2026-09-29.
Contains: Per the label Beli publishes, 3 capsules a day (90 capsules, 30 servings): folate 1,000 mcg DFE as L-5-MTHF, vitamin D3 4,000 IU (100 mcg), choline 400 mg, iron 18 mg (ferrous bisglycinate), iodine 201 mcg, vitamin B6 30 mg, vitamin B12 16.2 mcg, zinc 13 mg and vitamin K2 90 mcg. No omega-3, calcium or vitamin A. No fertility drug.
Marketed as: Marketed as a prenatal that promotes egg quality, hormonal balance and ovulation health.
Price: $50 per 29-day delivery
Sold via belibaby.com (subscription only), Amazon · A thorough prenatal on paper (methylfolate, 400 mg choline, gentle iron), but no trial shows these vitamins improve egg quality. On belibaby.com it is subscription only and renews every 29 days; Amazon sells a one-time bottle for about $55. Label and price read 2026-09-29.
Contains: Per the label Beli publishes, 2 capsules a day (60 capsules, 30 servings): folate 1,020 mcg DFE as L-5-MTHF, vitamin D3 2,000 IU, vitamin E 134 mg, vitamin C 100 mg, zinc 15 mg and selenium 70 mcg, plus L-carnitine 100 mg, L-arginine 200 mg, shilajit extract 250 mg, CoQ10 100 mg, taurine 110 mg and NAC 25 mg. No fertility drug.
Marketed as: Marketed to support sperm count, motility, morphology and DNA integrity, and normal testosterone levels.
Price: $50 per 29-day delivery
Sold via belibaby.com (subscription only), Amazon · Its antioxidant doses sit well below the amounts studied (L-carnitine 1 to 3 g, CoQ10 200 to 300 mg), and the largest trials of male antioxidant and folate-plus-zinc supplements (MOXI 2020, FAZST 2020) found no gain in semen quality or live births. Subscription only on belibaby.com, renewing every 29 days. Label and price read 2026-09-29.
Contains: Preconception bundles with methylated folate, CoQ10, vitamin D, and omega-3 DHA plus other micronutrients, in separate formulations for the person providing eggs and the person providing sperm. No fertility drug.
Marketed as: Marketed as preconception "Powers" bundles tailored separately for the egg side and the sperm side.
Price: ~$45-$55/mo per person
Sold via usa.birdandbe.com, Amazon · Adds CoQ10 and omega-3 on top of a standard prenatal, aimed at the preconception window. Convenient, but the added actives have only modest fertility evidence.
How we grade an ingredient
The evidence score is computed from the volume and type of primary studies (randomized trials and systematic reviews carry more weight than small or observational reports), so it measures how much real research exists, not how strong the marketing is. The product-label count is the number of real labels found for that ingredient in NIH's Dietary Supplement Label Database. Both link out so you can read the underlying records yourself.
Comparing clinics?
Supplements support nutritional adequacy; they are not a treatment. Compare fertility clinics by real IVF live-birth success rates, cost, and services, each figure cited to its source.