Vitamin D
A fat-soluble vitamin that acts like a hormone. Vitamin D receptors are present in the ovary, endometrium, and testis, and it is proposed to influence hormone production, endometrial receptivity, and sperm function.
Also known as cholecalciferol, vitamin D3.
At a glance
Updated monthly · checked 10 h agoVitamin D is a vitamin marketed as a fertility supplement. It is not a fertility drug. Its computed evidence score is ~79/100. Worth correcting a real deficiency (which is common), but not a fertility booster for people with normal levels; test first, do not megadose.
- Randomized trials
- 366
- Systematic reviews
- 689Computed
- Real product labels indexed
- 20 in the NIH DSLD
Marketed to correct deficiency and "improve fertility" and IVF success.
Worth correcting a real deficiency (which is common), but not a fertility booster for people with normal levels; test first, do not megadose.
What the evidence says
Computed from the volume and type of primary studies, not the strength of the marketing. Each figure below links to its live search.
Observational studies link low vitamin D with poorer fertility and IVF outcomes, but the supplementation trials are mixed and mostly show benefit only in people who are actually deficient. It is not proven to help those with normal levels.
- Cohort Profile Update: The Norwegian Mother, Father and Child Cohort (MoBa)2025 · 53 citations
- Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis2024 · 34 citations
- HOXA10 and HOXA11 in Human Endometrial Benign Disorders: Unraveling Molecular Pathways and Their Impact on Reproduction2025 · 32 citations
- Mixed probiotics modulated gut microbiota to improve spermatogenesis in bisphenol A-exposed male mice2024 · 31 citations
- Endometriosis and Nutrition: Therapeutic Perspectives2025 · 26 citations
Source: europepmc+pubmed+openalex · as of Sep 25, 2026
Real product labels
Actual marketed supplement products indexed by the NIH Dietary Supplement Label Database. A product being on a shelf is not evidence it works.
- Calcium Citrate + Vitamin DOff marketThe Vitamin ShoppeTablet or Pill
- Vitamin DEndo-met LaboratoriesCapsule
- Calcium Citrate + Vitamin DOff marketThe Vitamin ShoppeTablet or Pill
- Calcium Citrate + Vitamin DOff marketThe Vitamin ShoppeTablet or Pill
- Vitamin DOff marketNutriliteTablet or Pill
- Vitamin DOff marketNutriliteTablet or Pill
- Vitamin DOff marketNutriliteTablet or Pill
- Liposomal Vitamin DOff marketDr. MercolaCapsule
- Vitamin DOff marketNutriliteTablet or Pill
- Vitamin D ComplexOff marketThorne FXLiquid
- Calcium Citrate + Vitamin DOff marketThe Vitamin ShoppeTablet or Pill
- Calcium Citrate + Vitamin DOff marketThe Vitamin ShoppeTablet or Pill
- Vitamin DOff marketNutriliteTablet or Pill
- Calcium Citrate + Vitamin DOff marketThe Vitamin ShoppeTablet or Pill
- Vitamin D 10000Off marketMaritzMayer LaboratoriesSoftgel Capsule
- Vitamin D Gummy VitaminsOff marketNutrition NowGummy or Jelly
- Calcium Citrate + Vitamin DOff marketThe Vitamin ShoppeTablet or Pill
- Calcium Citrate Plus Vitamin DThe Vitamin ShoppeTablet or Pill
- Calcium Citrate + Vitamin DOff marketThe Vitamin ShoppeTablet or Pill
- Vitamin DEndo-met LaboratoriesCapsule
Source: NIH Dietary Supplement Label Database (DSLD) · as of Sep 30, 2026
What to watch for
Safe at recommended doses; excessive high-dose supplementation can cause high blood calcium. Best guided by a blood level rather than taken blindly.
What it actually is
Vitamin D is a single, characterized compound. Its structure, molecular formula, weight, and synonyms are on its PubChem compound record.
Source: PubChem (PUG-REST)