Lupron (leuprolide acetate)

GnRH agonist used to down-regulate, or as an alternative trigger

Updated weekly · checked 3 h ago

$64.02lowest posted cash price per 14-day kit

$197.61per kit, what pharmacies pay

77,110FAERS reports (all-time)

Lupron costs $64.02 per 14-day kit at Mark Cuban Cost Plus Drugs, the one source we found that posts a cash price (prices read Oct 4, 2026); a drug-price guide lists $133.80 per 14-day kit at an ordinary retail pharmacy; pharmacies themselves pay a national average of $197.61 per kit to acquire it (CMS NADAC).

Cost

What Lupron costs, by pharmacy

Every cash price we found posted by a pharmacy, TrumpRx.gov or the manufacturer, read on the seller's own page on Oct 4, 2026, compared per one unit and cheapest first. A retail drug-price guide's figure is shown for context.

Where, and the product as listedPer 14-day kit

Mark Cuban Cost Plus DrugsCash pharmacy
Leuprolide acetate 1 mg/0.2 mL kit, 14-day (2.8 mL): $64.02 (drug $59.02 + $5 pharmacy fee)
Shipping $5.25.
$64.02
read Oct 4, 2026
Drugs.com price guideRetail price guide
Leuprolide 14 mg/2.8 mL kit (1 mg/0.2 mL): $133.80 - $277.30
Drugs.com lists $133.80 to $277.30 for one kit, by product.
$133.80
read Oct 4, 2026

Cash prices only: with insurance that covers fertility drugs you pay your plan's share instead, and most manufacturer programs cannot be combined with insurance. Prices change; each row links to the page it was read on. Compare every IVF medication, or see what a whole cycle's drugs cost after TrumpRx.

What pharmacies pay

The national acquisition cost (CMS NADAC)

The national average price a US retail pharmacy pays to acquire each product, published weekly by CMS. A wholesale floor, not the price you are charged.

Package (NDC description)Per unit

Leuprolide 2WK 14 MG/2.8 ML Kt
NDC 70710176903 · effective Jun 3, 2026
$197.61
/ ea

Source: CMS National Average Drug Acquisition Cost (NADAC) · as of Jun 3, 2026

Across a whole stimulation cycle, all the medications together typically total $3,000–$7,000, which is the number that matters for a budget. See the full cycle breakdown or how families pay for it.

In a cycle

When it is given

Either as daily injections starting in the cycle before stimulation (long agonist protocol), or as a one-off trigger injection at the end of stimulation.

Leuprolide's marketed FDA labels cover endometriosis, uterine fibroids, prostate cancer, and central precocious puberty, so the label below describes those uses. Its role in an IVF protocol is off-label and well established in practice.

FDA label

What the prescribing information says

The current FDA structured product label, as published through openFDA and DailyMed. Excerpted verbatim, not summarised.

What the FDA label approves it for

1 INDICATIONS AND USAGE LUPRON DEPOT 3.75 mg is a gonadotropin-releasing hormone (GnRH) agonist indicated for: Endometriosis Management of endometriosis, including pain relief and reduction of endometriotic lesions. ( 1.1 ) In combination with a norethindrone acetate for initial management of the painful symptoms of endometriosis and for management of recurrence of symptoms. ( 1.1 ) Limitations of Use: The total duration of therapy with LUPRON DEPOT 3.75 mg plus add-back therapy should not exceed 12 months due to concerns about adverse impact on bone mineral density. ( 1.1 , 2.1 , 5.1 ) Uterine Leiomyomata (Fibroids) Concomitant use with iron therapy for preoperative hematologic improvement of women with anemia caused by fibroids for whom three months of hormonal suppression is deemed necessary. ( 1.2 ) Limitations of Use: LUPRON DEPOT 3.75 mg is not indicated for combination use with norethindrone acetate add-back therapy for the preoperative hematologic improvement of women with anemia caused by heavy menstrual bleeding due to fibroids. ( 1.2 ) 1.1 Endometriosis Monotherapy LUPRON DEPOT 3.75 mg is indicated for management of endometriosis, including pain relief and reduction of e

Dosage and administration

2 DOSAGE AND ADMINISTRATION LUPRON DEPOT 3.75 mg for 1-month administration, given by a healthcare provider as a single intramuscular injection. LUPRON DEPOT 3.75 mg has different release characteristics than LUPRON 11.25 mg and is dosed differently. ( 2.1 ) Do not substitute LUPRON DEPOT 3.75 mg for LUPRON DEPOT 11.25 mg. Do not administer LUPRON DEPOT 3.75 mg more frequently than once a month. Do not give a fractional dose of the LUPRON DEPOT 11.25 mg 3-month formulation, as it is not equivalent to a single dose of the LUPRON DEPOT 3.75 mg. Do not give a triple dose of the LUPRON DEPOT 3.75 mg, as it is not equivalent to a single dose of the LUPRON DEPOT 11.25 mg 3- month formulation. Reconstitute LUPRON DEPOT 3.75 mg prior to use. ( 2.2 ) Endometriosis: LUPRON DEPOT 3.75 mg administered as a single intramuscular (IM) injection once every month for up to six injections (6 months of therapy). LUPRON DEPOT may be administered alone or in combination with daily 5 mg tablet of norethindrone acetate (add-back). ( 2.1 ) If endometriosis symptoms recur after initial course of therapy, retreatment for no more than six months may be considered but only with the addition of norethindrone a

Warnings and cautions

5 WARNINGS AND PRECAUTIONS Loss of bone mineral density (BMD): Duration of treatment is limited by risk of bone mineral density. When using for management of endometriosis: combination use with norethindrone acetate is effective in reducing loss of BMD; do not retreat without combination norethindrone acetate. Assess BMD before retreatment. ( 1.1 , 1.2 , 5.1 ) Embryo-Fetal Toxicity: May cause fetal harm. Exclude pregnancy before initiating treatment if clinically indicated and discontinue use if pregnancy occurs. Use non-hormonal methods of contraception only. ( 5.2 ) Severe Cutaneous Adverse Reactions (SCARs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), occurred in patients treated with LUPRON DEPOT. Discontinue LUPRON DEPOT 3.75 mg if signs or symptoms of SCARs develop. Permanently discontinue if SCARs are confirmed. ( 5.3 ) Hypersensitivity reactions, including anaphylaxis, have been reported with LUPRON DEPOT 3.75 mg. ( 5.4 ) If LUPRON is administered with norethindrone acetate, the warnings and precautions for norethindrone acetate apply to the combination regimen. ( 5.8 ) 5.1 Loss of Bone Mineral Density LUPRON DEPOT 3.75 mg induces a hypoestrogen

Contraindications

4 CONTRAINDICATIONS LUPRON DEPOT 3.75 mg is contraindicated in women with the following: Hypersensitivity to gonadotropin-releasing hormone (GnRH), GnRH agonist analogs, including leuprolide acetate, or any of the excipients in LUPRON DEPOT 3.75 mg [see Warnings and Precautions ( 5.4 ) and Adverse Reactions ( 6.2 ) ] Undiagnosed abnormal uterine bleeding Pregnancy [see Warnings and Precautions ( 5.2 ) and Use in Specific Populations ( 8.1 ) ] When norethindrone acetate is administered with LUPRON DEPOT 3.75 mg, the contraindications to the use of norethindrone acetate also apply to this combination regimen. Refer to the norethindrone acetate prescribing information for a list of contraindications for norethindrone acetate. Hypersensitivity to GnRH, GnRH agonist analogs, including leuprolide acetate, or any of the excipients in LUPRON DEPOT 3.75 mg. ( 4 , 5.4 ) Undiagnosed abnormal uterine bleeding. ( 4 ) Pregnancy. ( 4 , 8.1 ) If LUPRON DEPOT 3.75 mg is administered with norethindrone acetate, the contraindications for norethindrone acetate also apply. ( 4 )

Label for Lupron Depot, source: openFDA structured product labels · as of Oct 4, 2026

Reported adverse events

What has been reported to the FDA

FAERS is a voluntary reporting system. A high count reflects how widely a drug is used and how often people report, not how dangerous it is, and a report is not proof the drug caused the event.

77,110reports, all-time

35,485flagged serious

hot flush 9,564
intercepted product preparation error 9,222
death 8,528
syringe issue 7,900
device leakage 6,230
wrong technique in product usage process 5,461

Source: openFDA FAERS (drug adverse events) · as of Sep 29, 2026

Common questions

About Lupron

How much does Lupron cost?

What is Lupron used for in fertility treatment?

A gonadotropin-releasing-hormone agonist. In a long agonist protocol it suppresses the body's own hormone signalling before stimulation begins; in antagonist cycles a single dose is sometimes used as the ovulation trigger instead of hCG, an approach associated with a lower risk of ovarian hyperstimulation. Either as daily injections starting in the cycle before stimulation (long agonist protocol), or as a one-off trigger injection at the end of stimulation.

How is Lupron given?

Injectable. Either as daily injections starting in the cycle before stimulation (long agonist protocol), or as a one-off trigger injection at the end of stimulation.

Is Leuprolide acetate FDA-approved for fertility use?

Other medications in a cycle

Posted cash prices are each seller's own published figure on the date shown; your price depends on the pharmacy, the quantity and your insurance. NADAC is the national average price a pharmacy pays to acquire a drug, not the price you are charged. Dosing here is quoted from the FDA label and is not a prescription: your protocol comes from your clinic. IVFcost.co is an informational data platform, not a medical provider, clinic, or laboratory. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Success rates depend heavily on individual circumstances and are not a promise of any outcome. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the clinic's own current figures.