Estradiol

Builds the uterine lining before a frozen embryo transfer

Sold as Estrace, estradiol tablets, Climara

Not yet available

In a cycle

When it is given

Started early in the cycle before a planned frozen transfer and continued while the lining is monitored by ultrasound, with progesterone added once the lining is ready.

Estradiol has no FDA-approved fertility indication; the label below is for its approved use in menopausal symptoms and related conditions. Preparing the endometrium for a frozen embryo transfer is an off-label use, and a standard one.

Cost

What it actually costs

The national average price a US pharmacy pays to acquire this drug, published by CMS for every priced package. A wholesale floor, not a retail quote.

No published generic acquisition price

CMS publishes an average acquisition cost only for drugs with generic pharmacy supply. Biologic gonadotropins usually have none, so no figure is shown here rather than an estimated one.

Across a whole stimulation cycle, medication typically totals $3,000–$7,000, which is the number that matters for a budget. See the full cycle breakdown or how families pay for it.

FDA label

What the prescribing information says

The current FDA structured product label, as published through openFDA and DailyMed. Excerpted verbatim, not summarised.

No FDA label indexed yet

The label feed has not returned a structured label for this medication. Nothing is shown rather than a paraphrase.

Common questions

About Estradiol

What is Estradiol used for in fertility treatment?

Estradiol is used to thicken and prepare the endometrium in a programmed (medicated) frozen-embryo-transfer cycle, before progesterone is added and the transfer is scheduled. Taken as tablets, or given as patches or vaginal preparations depending on the protocol. Started early in the cycle before a planned frozen transfer and continued while the lining is monitored by ultrasound, with progesterone added once the lining is ready.

How is Estradiol given?

Oral. Started early in the cycle before a planned frozen transfer and continued while the lining is monitored by ultrasound, with progesterone added once the lining is ready.

Why is there no listed price for Estradiol?

CMS publishes a national average acquisition cost only for drugs with generic pharmacy supply, and Estradiol has no published generic acquisition price. Rather than estimate one, this page leaves it absent. Across a whole IVF cycle, stimulation medication typically totals $3,000 to $7,000.

Is Estradiol FDA-approved for fertility use?

Other medications in a cycle

NADAC is the national average price a pharmacy pays to acquire a drug, not the cash price you are charged and not what a clinic bills for a medicated cycle. Dosing here is quoted from the FDA label and is not a prescription: your protocol comes from your clinic. IVFcost.co is an informational data platform, not a medical provider, clinic, or laboratory. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Success rates depend heavily on individual circumstances and are not a promise of any outcome. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the clinic's own current figures.