Luteal support and transfer prepVaginal / injectable

Progesterone (PIO shots, Endometrin, Crinone)

Luteal-phase support after IUI, retrieval, or embryo transfer

Sold as Prometrium

Updated weekly · checked 14 h ago

$0.40lowest posted cash price per 200 mg capsule

$0.23per capsule, what pharmacies pay

22,800FAERS reports (all-time)

Progesterone in oil: $22.25 per 10 mL vial (50 mg/mL) at an ordinary retail pharmacy (a drug-price guide); Endometrin: $15.60 per 100 mg insert at an ordinary retail pharmacy (a drug-price guide); Crinone 8%: $32.71 per applicator at an ordinary retail pharmacy (a drug-price guide); Progesterone capsules: $0.40 per 200 mg capsule (lowest posted, Mark Cuban Cost Plus Drugs), read Oct 4, 2026; pharmacies themselves pay a national average of $0.23 per capsule to acquire the cheapest form (CMS NADAC).

Cost

What Progesterone costs, by pharmacy

Every cash price we found posted by a pharmacy, TrumpRx.gov or the manufacturer, read on the seller's own page on Oct 4, 2026, compared per one unit and cheapest first. A retail drug-price guide's figure is shown for context.

Progesterone in oil

Where, and the product as listedPer 10 mL vial (50 mg/mL)

Drugs.com price guideRetail price guide
Progesterone in oil 50 mg/mL, 10 mL vial: $22.25 - $23.78
$22.25
read Oct 4, 2026

Endometrin

Where, and the product as listedPer 100 mg insert

Drugs.com price guideRetail price guide
Endometrin 100 mg, 21 inserts: from $327.59 for 21 insert
$15.60
read Oct 4, 2026

Crinone 8%

Where, and the product as listedPer applicator

Drugs.com price guideRetail price guide
Crinone 8% gel, 15 applicators (15 x 1.125 g): $490.58 for 16.875 (15 x 1.125 grams)
$32.71
read Oct 4, 2026

Progesterone capsules

Where, and the product as listedPer 200 mg capsule

Mark Cuban Cost Plus DrugsCash pharmacy
Progesterone 200 mg, 30 capsules: Your Drug Price With Us: $11.87
Shipping $5.25.
$0.40
read Oct 4, 2026

Cash prices only: with insurance that covers fertility drugs you pay your plan's share instead, and most manufacturer programs cannot be combined with insurance. Prices change; each row links to the page it was read on. Compare every IVF medication, or see what a whole cycle's drugs cost after TrumpRx.

Savings

Programs that lower the cost of Progesterone

Each program's own terms, read on its page. Eligibility is the program's to decide.

Heart for HeroesFerring
Menopur, Endometrin and Novarel 5,000 units at no cost; other medications are not covered.
Who qualifies: Veterans medically separated from active duty (Department of Defense category 2 or 3) with a service-related injury causing infertility that needs assisted reproduction, or their spouses, with no insurance coverage for IVF medications; residents of the 50 states and DC.
How to enroll: The physician certifies eligibility and faxes the enrollment form to MDR specialty pharmacy, which ships the medication free.
Read Oct 4, 2026
Crinone 8% Savings ProgramAbbVie
Most pay the first $15 of a fill, with up to $200 off a 30-day supply ($600 off 90 days) and up to $2,400 a year.
Who qualifies: Patients with commercial prescription insurance only; not valid for cash-paying patients or government programs.
How to enroll: Sign up at allergansavingscard.com/crinone and use the card at a participating pharmacy.
Read Oct 4, 2026

What pharmacies pay

The national acquisition cost (CMS NADAC)

The national average price a US retail pharmacy pays to acquire each product, published weekly by CMS. A wholesale floor, not the price you are charged.

Package (NDC description)Per unit

Progesterone 100 MG Capsule
NDC 70700016201 · effective Sep 23, 2026
$0.23
/ ea
Progesterone 200 MG Capsule
NDC 70700016301 · effective Sep 23, 2026
$0.40
/ ea
Progesterone 500 MG/10 ML Vial
NDC 63323026110 · effective Sep 23, 2026
$1.36
/ mL
$13.61 per 10 mL vial
Progesterone 100 MG Vag Insert
NDC 70700020170 · effective Sep 23, 2026
$10.88
/ ea
Endometrin 100 MG Vag Insert
NDC 55566650001 · effective Sep 23, 2026
$15.15
/ ea
Crinone 8% Gel
NDC 00023615108 · effective Sep 23, 2026
$27.97
/ g

Source: CMS National Average Drug Acquisition Cost (NADAC) · as of Sep 23, 2026

Across a whole stimulation cycle, all the medications together typically total $3,000–$7,000, which is the number that matters for a budget. See the full cycle breakdown or how families pay for it.

In a cycle

When it is given

Started around the retrieval or before a frozen embryo transfer and continued through the two-week wait, and often for several weeks into a pregnancy if the transfer works.

FDA label

What the prescribing information says

The current FDA structured product label, as published through openFDA and DailyMed. Excerpted verbatim, not summarised.

Boxed warning

WARNING: CARDIOVASCULAR DISORDERS, BREAST CANCER and PROBABLE DEMENTIA FOR ESTROGEN PLUS PROGESTIN THERAPY Cardiovascular Disorders and Probable Dementia Estrogens plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. (See CLINICAL STUDIES and WARNINGS , Cardiovascular disorders and Probable dementia . ) The Women's Health Initiative (WHI) estrogen plus progestin substudy reported increased risks of deep vein thrombosis, pulmonary embolism, stroke and myocardial infarction in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral conjugated estrogens (CE) [0.625 mg] combined with medroxyprogesterone acetate (MPA) [2.5 mg], relative to placebo. (See CLINICAL STUDIES and WARNINGS , Cardiovascular disorders . ) The WHI Memory Study (WHIMS) estrogen plus progestin ancillary study of the WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with daily CE (0.625 mg) combined with MPA (2.5 mg), relative to placebo. It is unknown whether this finding applies to younger postmenopausal women. (See CLINICAL STUDIES and WARNINGS

What the FDA label approves it for

INDICATIONS AND USAGE Progesterone capsules are indicated for use in the prevention of endometrial hyperplasia in nonhysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea.

Dosage and administration

DOSAGE AND ADMINISTRATION Prevention of Endometrial Hyperplasia Progesterone capsules should be given as a single daily dose at bedtime, 200 mg orally for 12 days sequentially per 28-day cycle, to postmenopausal women with a uterus who are receiving daily conjugated estrogens tablets. Treatment of Secondary Amenorrhea Progesterone capsules may be given as a single daily dose of 400 mg at bedtime for 10 days. Some women may experience difficulty swallowing progesterone capsules. For these women, progesterone capsules should be taken with a glass of water while in the standing position.

Warnings and cautions

WARNINGS See BOXED WARNING . 1. Cardiovascular disorders An increased risk of pulmonary embolism, deep vein thrombosis (DVT), stroke, and myocardial infarction has been reported with estrogen plus progestin therapy. Should any of these occur or be suspected, estrogen with progestin therapy should be discontinued immediately. Risk factors for arterial vascular disease (for example, hypertension, diabetes mellitus, tobacco use, hypercholesterolemia, and obesity) and/or venous thromboembolism (for example, personal history or family history of venous thromboembolism [VTE], obesity, and systemic lupus erythematosus) should be managed appropriately. a. Stroke In the Women’s Health Initiative (WHI) estrogen plus progestin substudy, a statistically significant increased risk of stroke was reported in women 50 to 79 years of age receiving daily CE (0.625 mg) plus MPA (2.5 mg) compared to women in the same age group receiving placebo (33 versus 25 per 10,000 women-years). The increase in risk was demonstrated after the first year and persisted. (See CLINICAL STUDIES .) Should a stroke occur or be suspected, estrogen plus progestin therapy should be discontinued immediately. b. Coronary Hear

Contraindications

CONTRAINDICATIONS Progesterone capsules should not be used in women with any of the following conditions: Progesterone capsules should not be used in patients with known hypersensitivity to its ingredients. Progesterone capsules contain peanut oil and should never be used by patients allergic to peanuts. Undiagnosed abnormal genital bleeding. Known, suspected, or history of breast cancer. Active deep vein thrombosis, pulmonary embolism or history of these conditions. Active arterial thromboembolic disease (for example, stroke and myocardial infarction), or a history of these conditions. Known liver dysfunction or disease. Known or suspected pregnancy.

Label for PROGESTERONE, source: openFDA structured product labels · as of Oct 18, 2026

Reported adverse events

What has been reported to the FDA

FAERS is a voluntary reporting system. A high count reflects how widely a drug is used and how often people report, not how dangerous it is, and a report is not proof the drug caused the event.

22,800reports, all-time

12,890flagged serious

headache 2,094
off label use 1,830
fatigue 1,795
drug ineffective 1,775
pain 1,482
nausea 1,475

Source: openFDA FAERS (drug adverse events) · as of Oct 20, 2026

Common questions

About Progesterone

How much does Progesterone cost?

Is there a savings program for Progesterone?

Yes: Heart for Heroes (Ferring): Menopur, Endometrin and Novarel 5,000 units at no cost; other medications are not covered. Crinone 8% Savings Program (AbbVie): Most pay the first $15 of a fill, with up to $200 off a 30-day supply ($600 off 90 days) and up to $2,400 a year. Each program states its own eligibility; read it on the program's page before you fill the prescription.

What is Progesterone used for in fertility treatment?

Progesterone supports the uterine lining after ovulation, IUI, or embryo transfer, and is what a frozen-transfer cycle uses in place of the hormone a natural corpus luteum would produce. Given vaginally as a capsule, insert, or gel, or as an intramuscular oil injection. Started around the retrieval or before a frozen embryo transfer and continued through the two-week wait, and often for several weeks into a pregnancy if the transfer works.

How is Progesterone given?

Vaginal / injectable. Started around the retrieval or before a frozen embryo transfer and continued through the two-week wait, and often for several weeks into a pregnancy if the transfer works.

Other medications in a cycle

Posted cash prices are each seller's own published figure on the date shown; your price depends on the pharmacy, the quantity and your insurance. NADAC is the national average price a pharmacy pays to acquire a drug, not the price you are charged. Dosing here is quoted from the FDA label and is not a prescription: your protocol comes from your clinic. IVFcost.co is an informational data platform, not a medical provider, clinic, or laboratory. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Success rates depend heavily on individual circumstances and are not a promise of any outcome. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the clinic's own current figures.